A true rarity: An RCT demonstrating a mortality benefit, but is it too good to be true? Matchett G, Gasanova I, Riccio CA, Nasir D, Sunna MC, Bravenec BJ, Azizad O, Farrell B, Minhajuddin A, Stewart JW, Liang LW, Moon TS, Fox PE, Ebeling CG, Smith MN, Trousdale D, Ogunnaike […]
hypothermia
6 posts
I have covered post-arrest hypothermia at length on this blog. (For example, here, here and here.) Although we are still waiting for definitive answers, I have always been rather skeptical, and the more trials we see, the more certain it is becoming that this whole enterprise was just a waste […]
As anticipated, my “monthly” summaries have become even less frequent, as I discovered that there are a few things in life even more enjoyable than reading the medical literature. I won’t apologize for choosing my 9 month old over evidence based medicine, but I will continue to put out these […]
We recently released an Emergency Medicine Cases Journal Jam episode covering all the available literature on ‘therapeutic’ hypothermia. Unfortunately, JAMA didn’t think to inform us that they had another big RCT in the pipeline, so the “CAPITAL CHILL” trial got left out of our summary. CAPITAL CHILL is somewhat unique, […]
My morning ritual of reading articles over coffee has transformed somewhat, such that there is a lot more playing with an infant, and a lot less evidence based medicine. Although the coffee isn’t going anywhere, it is usually cold by the time I have a free moment to get to […]
Despite ‘therapeutic’ hypothermia’s widespread use, the evidence for the practice has always been weak. I went through that evidence here. At that point, I tried to be optimistic, given the potentially positive results of the HYPERION trial, but I also noted the many problems with HYPERION that left me skeptical. […]