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Andexanet Alfa

Last year, the FDA granted andexanet alfa an accelerated approval as a reversal agent for factor Xa inhibitors, but based that decision on a complete lack of useable science. This decision is almost identical to the approval of idarucizumab, a debacle I have discussed previously. (At that time, I was […]

Andexanet Alfa: More garbage science in the New England Journal …

3 comments
oral antibiotics vs IV antibiotics for cellulitis

Complex orthopedic infections are traditionally managed with long courses of intravenous antibiotics. I have previously discussed, in the context of skin and soft tissue infection, that as long as the antibiotic is absorbed through the GI tract, there is no physiologic reason to think that IV antibiotics would be superior […]

Oral antibiotics are equivalent to IV (again) – the OVIVA …

1 comment
Dog Bite Evidence

I started writing this review of dog bite management a long time ago, but I abandoned it because I thought the word was already out. I thought this had been settled; that everyone knew these myths. However, a few recent conversations have highlighted the fact that the management of dog […]

Dog Bite Management: The Evidence

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The HOUR rule Clemency 2018

A critical appraisal of Clemency 2018 - the HOUR rule

The HOUR rule for opioid overdose (Clemency 2018)

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Babl 2018 clinical judgement

Emergency medicine loves decision rules. I can understand why, considering the apparent certainty they provide in a job that is anything but certain. However, decision tools are tests like any other, and can cause harm if they lead patients down inappropriate pathways. Although rare, the ideal test of a decision […]

Clinical judgement in pediatric head injury (Babl 2018)

heparin in ACS

An overview of the evidence indicating that heparin does not help in ACS

Heparin for Acute Coronary Syndrome: an evidence review

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heparin ACS

A retrospective look at heparin in ACS

Heparin in ACS (Chen 2018)

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Book list title image

I tend to read a lot. In previous years, one of the things I have found frustrating is forgetting which books I have already read when when hunting for my next read (especially with long series or authors with a huge number of titles). Therefore, this year I decided to […]

2018 Book List: A (non-medical) year in review

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Parachute RCT

A summary of Yeh 2018: Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial

Finally, an RCT of parachutes

3 comments
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