Should we use TXA for traumatic brain injury? This is a topic that received a lot of discussion after the CRASH3 trial was published. You can read my take on that trial here. In that blog post, I mention a second RCT that was completed long before CRASH3, but never […]
TXA
23 posts
It is already August! Even in COVID times, the days just seem to fly by. If you are looking for something boring to stretch those precious minutes out, I have another collection of evidence based medicine for you…
Massive GI bleeds can be very scary (for both the patient and the clinician), and it makes sense that we want to do everything possible to stop the bleeding. Until now, I have been using TXA (tranexamic acid) as a component of my resuscitation for massive GI bleeds. I reviewed […]
Time for another rapid recap of some important, inane, or interesting emergency medicine literature. Not a single paper about coronavirus though – you will have to stick to CNN for that. As always, the podcast version will be on the BroomeDocs podcast. Hold up – you want to shove that […]
For a long time, we have been planning an episode of the EMCases Journal Jam series that will look at the evidence for or against TXA in almost all clinical settings. (It has been in the planning stages for a long time, because it is un-surprisingly hard to coordinate the […]
Everyone knows about the CRASH-2 trial. It is now a decade old. It doesn’t seem like it desperately needs a new blog post, but I think that understanding this trial is important when trying to interpret the results of the newer CRASH-3 or WOMAN trials, and other TXA research that […]
It’s time for another edition of the research round up and BroomeDocs journal club – a collection of the most interesting emergency medicine research I have encountered in the last few months. This time around we have (of course) CRASH 3, some articles on laceration repair, improving the ED experience […]
TXA has been the darling drug of emergency medicine and critical care since the publication of the CRASH 2 trial back in 2010. CRASH 2 demonstrated a 1.5% decrease in mortality when TXA was given to trauma patients with significant bleeding. (CRASH 2 2010) These results led to the widespread […]
I have addressed the WOMAN trial before on First10EM. (Twice actually). Two mentions of a trial of TXA in postpartum hemorrhage might already seem a bit excessive for an emergency medicine blog. However, this trial has been discussed widely, and there seems to be some persistent confusion about the results […]