As far as I can tell, despite talking about the paper widely at conferences, I never included a write up of the original ANDROMEDA-SHOCK trial on First10EM. (Hernández 2019) (There is a massive file of all the topics I want to cover, and would cover if this was a job […]
sepsis
20 posts
Welcome back to another research roundup. This edition doesn’t have any immediate practice changers, but I think there are some very important topics. Enjoy. The BroomeDocs podcast: https://broomedocs.com/2024/09/first10em-journal-club-august-2024/ The BroomeDocs podcast on YouTube: (I am on vacation, so this will probably be inserted later.)
The pace of these literature summaries has decreased over the years, but perhaps that means that quality has increased? I think there is an interesting variety of papers this time around, from sepsis, to bullshit, to patient access to their own results online. A few huge papers dropped in the […]
Before jumping into this edition, I need to address the maternal kisses study discussed last time. Obviously the study was satire, and did an excellent job in making us laugh, but most satire studies (like those in the Christmas edition of the BMJ) are real studies. Apparently this paper was […]
Most septic patients don’t have a salt water deficit. Some people are (incorrectly) convinced that normal saline is a murder weapon. Should salt water remain the first line therapy for sepsis induced hypotension? The CLOVERS trial was just published, and it turns out that perhaps nothing you do matters.
Vitamin C in sepsis: Don’t LOVIT Lamontagne F, Masse MH, Menard J, et al; LOVIT Investigators and the Canadian Critical Care Trials Group. Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. N Engl J Med. 2022 Jun 23;386(25):2387-2398. doi: 10.1056/NEJMoa2200644. PMID: 35704292 This is a big […]
Another month, another collection of (hopefully) interesting medical publications. When trial results are too good to be true, think fraud? Sheldrick, K. Evidence of Fabricated Data in a Vitamin C trial by Paul E Marik et al in CHEST. Available at: https://kylesheldrick.blogspot.com/2022/03/evidence-of-fabricated-data-in-vitamin.html This is the first time I have ever […]
After two editions focused on COVID, it’s time to get back to some standard emergency medicine topics. (Yes, there are many more COVID papers to cover, but I am sort of sick of reading them.) This time we cover dog therapy in the ED, imaging for renal colic, hypothermia, vitamin […]
I have avoided commenting on vitamin C for sepsis, because commentary seemed rather unnecessary. The hype was obviously ridiculous. The chances of it helping were clearly low. The evidence of benefit was negligible. Others had widely discussed the papers, and most people seemed to be ignoring this “miracle cure.” However, […]