Another month, another collection of (hopefully) interesting medical publications. When trial results are too good to be true, think fraud? Sheldrick, K. Evidence of Fabricated Data in a Vitamin C trial by Paul E Marik et al in CHEST. Available at: https://kylesheldrick.blogspot.com/2022/03/evidence-of-fabricated-data-in-vitamin.html This is the first time I have ever […]
trauma
29 posts
Might the FAST exam be the most overused test in emergency medicine? If not the most overused (it does have to compete with the white blood cell count after all), perhaps it is the most overrated? Considering the sacrosanct position ultrasound holds in emergency medicine, even asking this question might […]
A key scientific lesson that I have discussed numerous times on this blog is that the interpretation of any new study must be placed within the context of what is already known about the topic. Although there must be equipoise for medical research to be ethical, equipoise does not mean […]
In the Rapid Review series, we briefly review the key points of a clinical review paper (or three). The topic this time: pediatric burns. The papers: Arbuthnot, M. K., & Garcia, A. V. (2019). Early resuscitation and management of severe pediatric burns. Seminars in Pediatric Surgery, 28(1), 73–78. https://doi.org/10.1053/j.sempedsurg.2019.01.013 Sheridan, […]
In this month’s edition of the research round-up, we have everything from Bayesian analysis to CPR in outer space. With that kind of range, hopefully I have found something interesting for every reader.
On paper, most of resuscitation is actually pretty easy. On paper, there are basic algorithms to follow. On paper, the steps are clear, and there are no obvious impediments to action. Unfortunately, real resuscitation rooms are nothing like textbooks. Knowing what to do is important, but far more important is […]
Should we use TXA for traumatic brain injury? This is a topic that received a lot of discussion after the CRASH3 trial was published. You can read my take on that trial here. In that blog post, I mention a second RCT that was completed long before CRASH3, but never […]
Everyone knows about the CRASH-2 trial. It is now a decade old. It doesn’t seem like it desperately needs a new blog post, but I think that understanding this trial is important when trying to interpret the results of the newer CRASH-3 or WOMAN trials, and other TXA research that […]
TXA has been the darling drug of emergency medicine and critical care since the publication of the CRASH 2 trial back in 2010. CRASH 2 demonstrated a 1.5% decrease in mortality when TXA was given to trauma patients with significant bleeding. (CRASH 2 2010) These results led to the widespread […]