Some big and potentially practice changing articles this month. (I tend to read ridiculous articles in my free time, which I have had very little of, and so there are no intubation in outer space or highly philosophical papers about the language this month. Don’t worry, there is still a […]
paxlovid
6 posts
As we have covered multiple times before, the evidence for paxlovid is heavily conflicted and mostly negative. There is very little reason to be using this agent clinically. However, despite an utter lack of evidence, many people have held out hope that paxlovid might be the miracle cure for the […]
Years ago, this started as the “articles of the month” and was truly a monthly undertaking. In order to become more regular with the BroomeDocs podcast, I am going to try once again to make this a monthly endeavor, although that might mean fewer articles in each edition. For the […]
As mentioned in my most recent review, publication bias has been a major concern when trying to decide whether to prescribe paxlovid. Pfizer rushed to publish their positive study (EPIC-HR), but refused to release the results of a second simultaneous study (EPIC-SR) that was stopped (due to futility) at the […]
My initial evidence update for Paxlovid (nirmatrelvir/ritonavir) contained exactly no evidence, because nothing was published, despite recommendations at that time from multiple organizations. Sadly, two years into the pandemic, a large portion of the medical community still seems willing to act based solely on drug company press releases. The EPIC-HR […]
I have avoided COVID therapies for a while, because so many people are already covering the topic, and honestly I am a little sick of COVID. However, with the OMICRON wave, everyone seems to have questions about therapies for COVID, so a quick evidence review seems appropriate. This article will […]