Some big and potentially practice changing articles this month. (I tend to read ridiculous articles in my free time, which I have had very little of, and so there are no intubation in outer space or highly philosophical papers about the language this month. Don’t worry, there is still a […]
COVID-19
44 posts
As we have covered multiple times before, the evidence for paxlovid is heavily conflicted and mostly negative. There is very little reason to be using this agent clinically. However, despite an utter lack of evidence, many people have held out hope that paxlovid might be the miracle cure for the […]
Years ago, this started as the “articles of the month” and was truly a monthly undertaking. In order to become more regular with the BroomeDocs podcast, I am going to try once again to make this a monthly endeavor, although that might mean fewer articles in each edition. For the […]
As mentioned in my most recent review, publication bias has been a major concern when trying to decide whether to prescribe paxlovid. Pfizer rushed to publish their positive study (EPIC-HR), but refused to release the results of a second simultaneous study (EPIC-SR) that was stopped (due to futility) at the […]
We are once again buried in a wave of viral respiratory illnesses, and much of the burden of illness is still COVID. I did a pretty thorough review of all COVID antiviral therapies in 2022, both on First10EM and on the EMCases Journal Jam, but that was 2 years ago. […]
The internet is alive with rumors of a simple, cheap, low-risk cure for long COVID. Sound too good to be true? That’s because it almost certainly is. Let’s talk about this COVIT-OUT trial and what it says about metformin.
The quixotic search for a cure to the common cold has spilled into an ongoing search for the cure to COVID. Honestly, I am sort of over it, but I do have to admit both would be pretty great. So, as I was recently informed on the internet, is zinc […]
When a scientific paper is immediately covered in lay media, you can almost guarantee a lot of incorrect takes. When a new paper comes out on any hotly debated topic, you are bound to see strong opinions lacking almost any nuance. The only thing that is somewhat strange about the […]
My initial evidence update for Paxlovid (nirmatrelvir/ritonavir) contained exactly no evidence, because nothing was published, despite recommendations at that time from multiple organizations. Sadly, two years into the pandemic, a large portion of the medical community still seems willing to act based solely on drug company press releases. The EPIC-HR […]