Hemophilia treatment

Type of Bleed Factor Level Required Initial Dose Factor VIII (Units/kg) Initial Dose Factor IX (Units/kg) 
Minor: Hemarthroses, hematuria 20-30%12.525
Moderate: GI bleeding, epistaxis, dental50%25   50
Severe: CNS, pharynx, retroperitoneal75-100%50100

Alternate options:


  • When factor VIII not available
  • 1 unit of factor VIII per 1mL


  • When factor VIII not available
  • 100 units of factor VIII per bag

DDAVP (Desmopressin acetate)

  • Release of extra VWF which carries extra factor VIII
  • Increases activity 2-5 times
  • 0.3 mcg/kg IV or sub-Q
  • 150 mcg nasal spray if <50 kg
  • 300 mcg nasal spray if >50kg

Other quick reference guides.

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