The management of sepsis has evolved dramatically since I was a trainee, just after Manny Rivers published his seminal sepsis protocol. At this point, I think we mostly know what we are doing. We give antibiotics. We look for a source and get source control. We give some fluids, but […]
Evidence Based Medicine
333 posts
Does N95 mask fitting really require you to me clean shaven? Might the practice actually be making you less safe?
The June 2026 First10em #FOAMEd Research Roundup Featuring appraisals of high quality recent RCTs, and for some reason Neanderthal dentistry
Strike 2 against whole blood. This time, mortality was 5% higher (but statistically negative) when whole blood was used in the prehospital setting. The TOWAR study
One of the downsides of subscribing to more than 50 journal feeds is the huge number of interesting papers that I flag for later, but never find time to fully appraise. I have been clearing some of these old PDFs out of my computer, but I figured that if the […]
It should be the easiest patient of the day. It is just a sore throat. The patient is fine. No signs of epiglottitis or deep space infection. They are clearly going home. But you are working with a curious student, and their questions unearth a tremendous amount of uncertainty. How […]
Only a few weeks have passed since I last wrote about negative trials for invasive therapy in pulmonary embolism. You wouldn’t think I would need to spend more time talking about negative research, but the HI-PETHO trial is different, because it is reported as positive, and some people seem to […]
Despite incredibly underwhelming evidence from the outset, a massive amount of money was spent (or wasted) on Paxlovid during the COVID pandemic. Some of the issues are endemic to medical science. When we allow companies to test their own products with billions of dollars on the line, the results are […]
I think there are some very interesting papers in here this month. There are a couple big RCTs, but if you aren’t in the mood for EBM right now, I suggest at least having a look at the final paper, and imagine yourself volunteering to participate.