Last year, the FDA granted andexanet alfa an accelerated approval as a reversal agent for factor Xa inhibitors, but based that decision on a complete lack of useable science. This decision is almost identical to the approval of idarucizumab, a debacle I have discussed previously. (At that time, I was […]
Evidence Based Medicine
91 posts
Complex orthopedic infections are traditionally managed with long courses of intravenous antibiotics. I have previously discussed, in the context of skin and soft tissue infection, that as long as the antibiotic is absorbed through the GI tract, there is no physiologic reason to think that IV antibiotics would be superior […]
I started writing this review of dog bite management a long time ago, but I abandoned it because I thought the word was already out. I thought this had been settled; that everyone knew these myths. However, a few recent conversations have highlighted the fact that the management of dog […]
Emergency medicine loves decision rules. I can understand why, considering the apparent certainty they provide in a job that is anything but certain. However, decision tools are tests like any other, and can cause harm if they lead patients down inappropriate pathways. Although rare, the ideal test of a decision […]
A summary of Yeh 2018: Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
