As we have covered multiple times before, the evidence for paxlovid is heavily conflicted and mostly negative. There is very little reason to be using this agent clinically. However, despite an utter lack of evidence, many people have held out hope that paxlovid might be the miracle cure for the […]
ebm reviews COVID
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As mentioned in my most recent review, publication bias has been a major concern when trying to decide whether to prescribe paxlovid. Pfizer rushed to publish their positive study (EPIC-HR), but refused to release the results of a second simultaneous study (EPIC-SR) that was stopped (due to futility) at the […]
The time has come to learn from the pandemic; to learn from our mistakes (and hopefully a few successes). There are many topics to choose from. In future posts, I plan to be very positive about the tremendous work done by so many colleagues. I will probably also have to […]
We are once again buried in a wave of viral respiratory illnesses, and much of the burden of illness is still COVID. I did a pretty thorough review of all COVID antiviral therapies in 2022, both on First10EM and on the EMCases Journal Jam, but that was 2 years ago. […]
The internet is alive with rumors of a simple, cheap, low-risk cure for long COVID. Sound too good to be true? That’s because it almost certainly is. Let’s talk about this COVIT-OUT trial and what it says about metformin.
The quixotic search for a cure to the common cold has spilled into an ongoing search for the cure to COVID. Honestly, I am sort of over it, but I do have to admit both would be pretty great. So, as I was recently informed on the internet, is zinc […]
When a scientific paper is immediately covered in lay media, you can almost guarantee a lot of incorrect takes. When a new paper comes out on any hotly debated topic, you are bound to see strong opinions lacking almost any nuance. The only thing that is somewhat strange about the […]
My initial evidence update for Paxlovid (nirmatrelvir/ritonavir) contained exactly no evidence, because nothing was published, despite recommendations at that time from multiple organizations. Sadly, two years into the pandemic, a large portion of the medical community still seems willing to act based solely on drug company press releases. The EPIC-HR […]
This is part of the ongoing series of articles updating the evidence on current COVID-19 therapies. The rest of the series can be found here, and there is probably more to come. This article will cover the evidence for inhaled steroids in COVID-19. I already covered the evidence for budesonide […]