I have discussed the ongoing battle between normal saline and ‘balanced fluids’ many times in the past. First, there was the SPLIT trial, a double blind cluster RCT of 2200 ICU patients that showed no difference between saline and Plasma-Lyte 148. (Young 2015) Next, we had the SMART trial, an unblinded cluster RCT of 15,000 … Continue reading The ongoing saga of normal saline versus balanced fluids