There is no perfect study of stress testing. There are no RCTs of stress testing in emergency department patients, so we cannot say with certainty whether they help or hurt. The studies describing test characteristics are also imperfect. Partly, that is because people try to use stress tests to identify […]
In the first edition of the research roundup for 2019 we are going to cover pediatric head injury, oral antibiotics for complicated orthopedic infections, shaving eyebrows, bad science in the New England Journal of Medicine, a decision rule for opioid overdose, shark bites, heparin for ACS, cardiac monitoring in syncope, […]
Last year, the FDA granted andexanet alfa an accelerated approval as a reversal agent for factor Xa inhibitors, but based that decision on a complete lack of useable science. This decision is almost identical to the approval of idarucizumab, a debacle I have discussed previously. (At that time, I was […]
Complex orthopedic infections are traditionally managed with long courses of intravenous antibiotics. I have previously discussed, in the context of skin and soft tissue infection, that as long as the antibiotic is absorbed through the GI tract, there is no physiologic reason to think that IV antibiotics would be superior […]