Levetiracetam versus Phenytoin in Status Epilepticus (ConSEPT and EcLiPSE)

Status epilepticus is associated with a high degree of morbidity and mortality. Approximately ⅓ of patients have long term neurologic sequela, and mortality is 3-5%. (Chin 2006; Raspall-Chaure 2006) First line treatment is with benzodiazepines, but benzos will fail approximately 30-40% of the time. (Appleton 2008) Therefore, an effective second line agent is essential. Despite … Continue reading Levetiracetam versus Phenytoin in Status Epilepticus (ConSEPT and EcLiPSE)