Isoniazid overdose

A brief summary of the initial resuscitation of a patient with isoniazid toxicity


You get a patch from an EMS crew on route with a 3 year old boy in status epilepticus, with 5 minutes of tonic clonic seizure activity unresponsive to the first dose of midazolam. You gather your team and perform a quick pre-brief, reviewing everyone’s expected role, the algorithm you will follow, and the anticipated pediatric doses. You gather all the necessary pediatric equipment and have the broselow tape ready. You are feeling very confident, but when paramedics role through the door, you encounter a mother screaming about her child being poisoned. Apparently grandma is being treated for tuberculosis, and the pills were all over the ground. The child is still in an active tonic-clonic seizure as the paramedics transfer him to the resuscitation bay stretcher…

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Management of Delirium Tremens

A brief guide to the initial management of severe alcohol withdrawal or delirium tremens in the emergency department


A 58 year old man is brought into the emergency department by his girlfriend because she thinks he had a seizure at home. He has a long history of alcoholism, and usually drinks about 1 litre of Newfoundland Screech rum every day. However, he had to stop drinking 3 days ago because of a brief stint in jail. He is tremulous, diaphoretic, confused, and complaining of visual hallucinations. His vital signs are a temperature of 37.8°C, heart rate 155, blood pressure 166/99, respiratory rate 22, and oxygen saturation 99% on room air…

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Management of calcium channel blocker overdose in the emergency department

A brief review of the management of the critically ill patient with a calcium channel blocker overdose in the emergency department


A 52 year old man is brought to your community emergency department by EMS because he ingested an entire bottle of diltiazem after a fight with his ex-wife. The patient is drowsy and mumbling incoherently. The paramedic team reports his vital signs as a heart rate of 51, blood pressure of 82/37, respiratory rate of 23, and oxygen saturation of 91%. A finger stick glucose was 23mmol/L (414mg/dL for Americans)…

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Local anesthetic toxicity

A simplified approach to the initial assessment and management of emergency department patients with local anesthetic toxicity


You are looking after a 30 year old woman with an isolated femur fracture, and decide to help manage her pain with a nerve block. Unfortunately, your ultrasound machine was broken so you attempted to do the femoral nerve block blind, using bupivacaine. Shortly after injecting the anesthetic, she complains of a headache, dizziness, and numb lips. Then she loses consciousness. You glance at the monitor and notice a wide complex tachycardia.

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